Endocrine Abstracts

Despite rarer in children than in adults, GH-secreting pituitary adenomas are often more aggressive, being challenging cases during childhood. Somatic changes (tall stature and acromegalic features), optic chiasma syndrome or metabolic and cardiovascular impact of GH excess trigger diagnosis and requires aggressive management. Treatment options are surgery, radiotherapy and medical therapy using somatostatin analogues, dopamine agonists and recently, GH receptor antagonists &#...

Prolactinoma (PRM) treatment is based upon dopamine agonists, cabergoline (CAB) being one of the most used in the last decade. Sensitivity to CAB varies in terms of tumour volume and PRL secretion, up to 8–15% of PRM being defined as resistant. Since it is known that increasing the dosage improves the response rate, we aimed to measure plasma CAB levels in PRM patients under this treatment in a prospective interventional study.Patients and methods: ...

Cabergoline (CAB) is a selective dopamine D2-receptor agonist with long-lasting action, highly effective in treating micro- and macroprolactinoma. However, the clinical response to cabergoline can be seen only after several months of treatment, allowing the tumor shrinkage and decrease of prolactin. Despite most prolactinomas are responsive to CAB, there are up to 8% of cases in which tumor responsivity is limited. In order to asses the sensitivity to Cab, we aimed to develop ...

A 50–year-old female with a 2 year-history of hypertension and diabetes was admitted to a county hospital, where treatment with clonidine and beta-blockers was started, without success. Abdominal CT showed a large left adrenal tumour, and her initial blood pressure (BP) was over 300/170 mmHg, which dropped to 80/30 mmHg. She was transferred for evaluation of a possible pheochromocytoma (PHEO). At admission her BP was 260/160 mmHg, heart rate (HR) 120 bpm, with anxiety, di...